Science and Technology links (December 1st 2018)

  1. Autism affects about 1% of the population and four times as many males as females.
  2. In older highly educated people, drinking 2 cups of coffee a day is associated with a reduced mortality rate of 22%. (This does not mean that drinking coffee makes you less likely to die, but it might.)
  3. Amazon, the e-commerce giant, is entering the chip-making business with its AWS Graviton processors, designed for cloud servers and based on an ARM architecture (like the processor in your phone). The initial reports are somewhat negative.
  4. Student assignments are graded automatically at the University of Cafornia Berkeley, and the result is that

    ratings for teaching effectiveness have reached their highest level ever in recent semesters.

    (Credit: S. Downes)

  5. A Chinese professor helped produced two genetically edited babies. The intention is that they be immune to HIV. Harvard’s professor George Church is supportive of this bold move.

Science and Technology links (November 18th 2018)

  1. It seems that reducing your carbohydrate (sugar) intake might be a good way to lose weight:

    lowering dietary carbohydrate increased energy expenditure during weight loss maintenance. This metabolic effect may improve the success of obesity treatment, especially among those with high insulin secretion.

    I should warn that this study refers to “lowering sugar” not getting rid of it entirely.

  2. 85% of the more than $100bn a year spent on medical research globally is wasted avoidably
  3. Collison and Nielsen write:

    science has slowed enormously per dollar or hour spent. That evidence demands a large-scale institutional response. It should be a major subject in public policy, and at grant agencies and universities

    While I accept their demonstration, it is not clear what (if anything in particular) is causing this lack of productivity.

    Collison and Nielsen fall short of offering a solution. Maybe we ought to reinvent discovery?

  4. A man is going to court so that he can be considered 20 years younger than what his birth date indicates.

Science and Technology links (November 10th, 2018)

  1. It already takes more energy to operate Bitcoin than to mine actual gold. Cryptocurrencies are responsible for millions of tons of CO2 emissions. (Source: Nature)
  2. Half of countries have fertility rates below the replacement level, so if nothing happens the populations will decline in those countries” (source:BBC)
  3. According to Dickenson et al., 8.6% of us (7.0% of women and 10.3% of men) have difficulty controlling sexual urges and behaviors.
  4. A frequently prescribed drug family (statins) can increase your risk of suffering from ALS by a factor of 10 or 100.
  5. Countries were people are expected to live longest in 2040 are Spain, Japan, Singapore, Switzerland, Portugual, Italy, Israel, France, Luxembourgh, Australia. Not included in this list is the USA.
  6. Smart mirrors could monitor your mood, fitness, anxiety levels, heart rate, skin condition, and so forth.
  7. When you are trying to determine whether a drug is effective, it is tempting to look at published papers and see whether they all agree on the efficacity of the drug. This may be quite wrong: Turner et al. show a strong bias whereas negative results are never published.

    Studies viewed by the FDA as having negative or questionable results were, with 3 exceptions, either not published (22 studies) or published in a way that, in our opinion, conveyed a positive outcome (11 studies). According to the published literature, it appeared that 94% of the trials conducted were positive. By contrast, the FDA analysis showed that 51% were positive. Separate meta-analyses of the FDA and journal data sets showed that the increase in effect size ranged from 11 to 69% for individual drugs and was 32% overall.

    Simply put, it is far easier and profitable to publish positive results so that’s what you get.

    This means that, by default, you should always downgrade the optimism of the litterature.

    Simply put: don’t be too quick to believe what you read, even if it is comes in the form of a large set of peer-reviewed research papers.

  8. Richard Jones writes “Motivations for some of the most significant innovations weren’t economic“.
  9. Cable and satellite TV is going away.
  10. “What if what students really want is not to be learners, but alumni?” People will prefer an academically useless program from Harvard to a complete graduate program from a lowly school because they badly want to say that they went to Harvard.
  11. Drinking coffee abundantly protects from neurodegenerative diseases.

Science and Technology links (November 3rd, 2018)

  1. Bitcoin, the cryptocurrency, could greatly accelerate climate change, should it succeed beyond its current speculative state.
  2. Crows can solve novel problems very quickly with tools they have never seen before.
  3. The new video game Red Dead Redemption 2 made $725 million in three days.
  4. Tesla, the electric car company, is outselling Mercedes Benz and BMW while making a profit.
  5. Three paralyzed men are able to walk again thanks to spinal implants (source: New York Times). There are nice pictures.
  6. Human beings live longer today than ever. In the developed world, between 1960 and 2010, life expectancy at birth went up by nearly 20 years. It consistently goes up by about 0.12 years per year. However, it is not yet clear how aging and death have evolved over time. Some believe that there is a “compression” effect: more and more of us reach a maximum, and then we suddenly all die at around the same age. This would be consistent with a hard limit on human lifespan and I think it is the scenario most biologists would expect. There is also the opposite model: while most of us die at around the same age, some lucky ones survive much longer. According to Zuo et al. (PNAS) both models are incorrect statistically. Instead, the curve is advancing as a wave front. This means that as far as death is concerned, being 68 today is much like being 65 a generation ago. This is surprising.

    (…) we find no support for an approaching limit to human lifespan. Nor do our results suggest that endowments, biological or other, are a principal determinant of old-age survival.

    Assuming that Zuo et al. are correct, I do not think we have a biological model at the ready to explain this statistical phenomenon.

  7. Suppose that you gave a cocktail of drugs approved for human consumption to worms. By how much do you think you could extend their lifespan? The answer is at least by a factor of two. They tried their best cocktails with fruit flies and showed benefits there as well. It is much harder to manipulate the lifespan of large mammals like human beings, but these results support the theory that drug cocktails could increase human lifespans. They may already being doing so.
  8. Amazon is hiring fewer workers, maybe because it is getting better at automation. (speculative) It seems that Amazon is mostly denying the story, hinting that they are still creating more and more jobs.
  9. No primate except for human beings, undergoes menopause. Very few animals have menopause: primarily some whales and human beings. I don’t think we know why menopause evolved.
  10. Total direct greenhouse gas emissions from U.S. livestock have declined 11.3 percent since 1961, while production of livestock meat has more than doubled.
  11. Male and female animals respond very differently to anti-aging strategies and they age very differently:

    One particularly odd thing in humans is that though women live longer, they are nonetheless more prone to miserable but non-deadly ailments such as arthritis (…) Lethal illnesses such as heart disease and cancer strike men more often. Although Alzheimer’s strikes women more than men, for unknown reasons.

    We do not know why there is such a sharp difference between males and females regarding health and longevity. However, some believe that the current historical fact that women live many years more than men is due to the fact that antibiotics disproportionally helped the health of women.

  12. Vegans more frequently suffer from bone fractures.
  13. Teaching by presenting worked examples seems to be most efficient. Students get the best grades with the least work.This appears self-evident to me. It is curious why worked examples are not more prevalent in teaching.
  14. A company called Grifols claims to have a drug that can measurably slow down the progression of Alzheimer’s. For context, we currently have no therapy to slow or reverse Alzheimer’s, so even a small positive effect would be a tremendous breakthrough. However, there has been many, many false news regarding Alzheimer’s and this report appears quite preliminary.

Science and Technology links (July 15th, 2018)

  1. One of the problems that occur with aging is that your immune system becomes less efficient, less able to learn.
    If we could reverse this effect, it would be akin to rejuvenation. And it seems to be around the corner according to a new article published by Science:

    The objective of this phase 2a randomized, placebo-controlled clinical trial was to determine whether low-dose mTOR inhibitor therapy enhanced immune function and decreased infection rates in 264 elderly subjects given the study drugs for 6 weeks. A low-dose combination (…) was associated with a significant (P = 0.001) decrease in the rate of infections reported by elderly subjects for a year after study drug initiation. In addition, we observed an up-regulation of antiviral gene expression and an improvement in the response to influenza vaccination in this treatment group. Thus, selective TORC1 inhibition has the potential to improve immune function and reduce infections in the elderly.

  2. Nature reports on a technique that could massively accelerate artificial neural networks:

    Our method replaces artificial neural networks fully-connected layers with sparse ones before training, reducing quadratically the number of parameters, with no decrease in accuracy.

    Whether this makes it to production server is another story but “reducing quadratically the number of parameters” sounds impressive.

    In related news, you can run neural network software on DNA to recognize molecular patterns.

  3. We live longer and longer, but what good is that if your mind is not intact? Thankfully, between 2000 and 2010, most of the increase in life expectancy has been concentrated in cognitively healthy years in this 10 year period.
  4. As we age, we accumulate “old” cells called senescent cells. They should die but they fail to do so. It seems that senescent cells are really bad for us. Thankfully we can clear them out and get benefits, the evidence is growing:

    Here we demonstrate that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues. Transplanting even fewer senescent cells had the same effect in older recipients and was accompanied by reduced survival, indicating the potency of senescent cells in shortening health- and lifespan. The senolytic cocktail, dasatinib plus quercetin, which causes selective elimination of senescent cells, decreased the number of naturally occurring senescent cells and their secretion of frailty-related proinflammatory cytokines in explants of human adipose tissue. Moreover, intermittent oral administration of senolytics to both senescent cell–transplanted young mice and naturally aged mice alleviated physical dysfunction and increased post-treatment survival by 36% while reducing mortality hazard to 65%.

  5. Vegetarian men are more likely to suffer from depression.
  6. Naked mole rats are ugly mammals that are interesting because they are largely immune to cancer and aging. Shar-Pei dogs are dogs with deeply wrinkled skin. Might they also be resistant to cancer? It looks like they are, indeed. However, sadly, Shar-Pei dogs are short lived due to other health problems.
  7. In England, more than half (57%) of those who die are older than 80.
  8. Australians show that you can wipe out disease-carrying mosquitoes using genetic engineering.
  9. A heart disease drug seems to be able to at least partially reverse Type 1 diabetes, in some cases:

    addition of once-daily oral verapamil may be a safe and effective novel approach to promote endogenous beta cell function and reduce insulin requirements and hypoglycemic episodes in adult individuals with recent-onset T1D.

    In related research, Omega-3 fatty acids could help with Type 1 diabetes.

  10. Though Siri and Alexa can understand what you are saying, most of the time, they cannot isolate your voice in a crowd of people talking. It is essentially an unsolved problem in speech recognition. It seems that some researchers made progress, bringing the error rate down from 90% to 30%, under some conditions. The problem remains unsolved (30% is high).